@Article{Kamiński2009,
journal="Archives of Medical Science",
issn="1734-1922",
volume="5",
number="3",
year="2009",
title="Clinical researchShort period of exercise causes rapid increase of serum interleukin 6 with no effect on its soluble receptor",
abstract=" Introduction:  Interleukin 6 (IL-6) is a pleiotropic cytokine secreted by skeletal muscle during exercise, intermediating beneficial effects of physical training such as increasing insulin sensitivity and suppressing pro-inflammatory cytokines. As IL-6 actions depend on its soluble receptor (sIL-6R), the changes in IL-6 concentration should be analyzed together with the changes of the sIL-6R.   Material and methods:  We have performed a study to investigate the effects of short term exercise on plasma concentrations of IL-6 and sIL-6R in healthy subjects. Twenty four healthy, non-obese males (age 40-59) were included in the study. A 9 min standard Bruce protocol treadmill stress test was performed. Plasma IL-6 and sIL-6R concentrations were assessed prior to the exercise test and immediately after the 9th min of exercise.   Results:  Resting plasma IL-6 and sIL-6R concentrations were 1.54 \&#177;0.43 pg/ml and 40 \&#177;10.5 ng/ml respectively. After exercise IL-6 concentration increased to 2.08 \&#177;0.89 pg/ml (p < 0.005 in comparison to baseline). The concentration of sIL-6R was similar to the initial values (39.6 \&#177;7.4 ng/ml). In regression analysis the extent of IL-6 increase during exercise depended mainly on the maximal heart rate and systolic blood pressure. Analysis of ROC revealed that patients with lower maximal heart rate (< 140 bpm) and systolic blood pressure (< 160 mm Hg) were more likely not to have IL-6 rise after exercise.   Conclusions:  In healthy males, brief exercise causes significant increase of plasma IL-6 concentration that depends on hemodynamic effects of exercise, whereas the plasma concentration of IL-6 circulating receptor remains stable.",
author="Kamiński, Karol
and Jasiewicz, Małgorzata
and Knapp, Małgorzata
and Jackowska, Anna
and Latocha-Korecka, Grażyna
and Waszkiewicz, Ewa
and Musiał, Włodzimierz J.",
pages="364--370",
url="https://www.termedia.pl/Clinical-research-Short-period-of-exercise-causes-rapid-increase-of-serum-interleukin-6-with-no-effect-on-its-soluble-receptor,19,13476,1,1.html"
}