@Article{Gutkowski2009,
journal="Gastroenterology Review/Przegląd Gastroenterologiczny",
issn="1895-5770",
volume="4",
number="5",
year="2009",
title="The use of azathioprine and 6-mercaptopurine in the treatment of inflammatory bowel diseases",
abstract="Azathioprine (AZA) and 6-mercaptopurine (6-MP) have been used for many years in the treatment of inflammatory bowel diseases (IBD). AZA is a prodrug that is metabolized to 6-MP, which in turn is metabolized to several metabolites including 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP). The most important enzyme responsible for metabolism of purine analogues is thiopurine methyltransferase (TPMT), which activity has direct or indirect influence on serum levels of 6-MMP and 6-TG. Detection of low or absent TPMT enzymatic activity before introducing therapy with AZA or 6-MP helps to avoid potentially life-threatening post-medicament toxicity. In this review the current knowledge of rational dosage and monitoring of therapeutic effects of AZA and 6-MP in patients with IBD based on understanding  of their pharmacodynamics have been presented.",
author="Gutkowski, Krzysztof
and Hartleb, Marek",
pages="225--230",
url="https://www.termedia.pl/The-use-of-azathioprine-and-6-mercaptopurine-in-the-treatment-of-inflammatory-bowel-diseases,41,13588,1,1.html"
}