@Article{Sikora2009,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="13",
number="5",
year="2009",
title="The role of TCR-z expression in immunosuppression induced by tumour",
abstract="The z-chain is a 16-kDa molecule associated with the T-cell receptor TCR-CD3 complex in T lymphocytes and FcgRIII in NK cells. The z functions as a transmembrane signaling molecule. Several distinct mechanisms may be responsible for decreased/absent z in  T cells of patients with cancer. Assessment of z-chain expression in the course of various diseases shows changes in expression of this molecule in immune cells. Immunohistochemical evaluation of z expression can link it to the conventional markers of prognosis or survival. Monitoring for z expression is useful for assessing immune competence in these patients and for following changes in immune competence during anticancer therapies. Correlations made between clinical findings, pathologic results, and z expression in immune cells suggest that low/absent z is predictive of poor prognosis and survival in patients with cancer.",
author="Sikora, Jan",
pages="221--226",
url="https://www.termedia.pl/The-role-of-TCR-z-expression-in-immunosuppression-induced-by-tumour,3,13628,1,1.html"
}