@Article{Uyarel2009,
journal="Archives of Medical Science",
issn="1734-1922",
volume="5",
number="4",
year="2009",
title="Contrast-induced nephropathy in patients undergoing primary angioplasty for acute myocardial infarction: incidence, a simple risk score, and prognosis",
abstract=" Introduction:  Patients undergoing primary angioplasty for ST-segment elevation myocardial infarction (STEMI) may be at increased risk of contrast-induced nephropathy (CIN) because of inadequate prophylaxis. We investigated the incidence, predictive factors, and outcomes of CIN after primary percutaneous coronary intervention (PCI).   Material and methods:  2521 consecutive STEMI patients (mean age 56.5 \&plusmn;11.8, years, 2091 male, baseline creatinine 0.97 \&plusmn;0.3 mg/dl) undergoing primary PCI were retrospectively enrolled in the present study.   Results:  Contrast-induced nephropathy was defined as an increase in serum creatinine level ł 0.5 mg/dl or ł 25% from baseline within 72 h of radiocontrast administration. 630 patients (25%) developed CIN. Patients with baseline creatinine > 1.5 mg/dl developed CIN more often than those with creatinine Ł 1.5 mg/dl (45.9 vs. 24%, p   250 ml (OR 1.34, 95% CI 1.01-1.78, p = 0.04), age ł 75 years (OR 2.07, 95% CI 1.36-3.12, p = 0.001), anterior infarction (OR 1.26, 95% CI 0.99-1.60, p = 0.05). Higher in-hospital mortality rate was observed in patients developing CIN (9.5 and 1.2%, p < 0.001). Cox regression analysis showed that CIN was a predictor of long-term cardiovascular mortality (hazard ratio [HR] 1.90, 95% CI 1.16-3.12, p = 0.01) and major cardiovascular events (HR 1.34, 95% CI 1.04-1.72, p = 0.025).   Conclusions:  Contrast-induced nephropathy in patients with STEMI undergoing primary PCI is associated with a markedly increased risk of major cardiovascular events as well as in-hospital and long-term mortality.",
author="Uyarel, Huseyin
and Cam, Nese
and Ergelen, Mehmet
and Akkaya, Emre
and Ayhan, Erkan
and Isik, Turgay
and Cicek, Gokhan
and Gunaydin, Zeki Yuksel
and Osmonov, Damirbek
and Gul, Mehmet
and Demirci, Deniz
and Guney, Mehmet Rasit
and Ozturk, Recep
and Yekeler, Ibrahim",
pages="550--558",
url="https://www.termedia.pl/Contrast-induced-nephropathy-in-patients-undergoing-primary-angioplasty-for-acute-myocardial-infarction-incidence-a-simple-risk-score-and-prognosis,19,13912,1,1.html"
}