@Article{Catakoglu2009,
journal="Archives of Medical Science",
issn="1734-1922",
volume="5",
number="4",
year="2009",
title="The influence of aspirin resistance on non-fatal coronary events following percutaneous coronary interventions",
abstract=" Introduction:  Aspirin resistance is associated with unfavourable prognosis, including a higher incidence of myocardial infarction, stroke, and cardiovascular death among stable cardiovascular patients, a higher incidence of re-occlusion after peripheral angioplasty, and myonecrosis following elective percutaneous coronary interventions (PCI). The objective of this study was to evaluate the relationship between aspirin resistance and non-fatal clinical endpoints during the long term follow-up following successful PCI.    Material and methods:  A total of 100 subjects with angiographically diagnosed coronary artery disease and treated with elective, non-urgent intracoronary stent implantation between October 2001 and June 2002 were enrolled in the study. All patients were under regular aspirin (300 mg) treatment. PFA-100 analyzer was used to assess the platelet functions. Aspirin resistance was defined as a collagen/epinephrine closure time (CTCEPI) < 186 s. The study end-point was the composite of non-fatal coronary events which included non-fatal MI, coronary artery bypass graft surgery (CABG) or repeat PCI, during the 2-year follow-up period after the index PCI.   Results:  The incidence of aspirin resistance was found to be significantly higher (p = 0.021) in patients with non-fatal coronary events (22.4%) compared to those who did not have (5.9%). Aspirin resistance was found to be an independent risk factor for non-fatal coronary events after adjusted for other potential risk factors (p = 0.019).    Conclusions:  Despite regular treatment with aspirin, the incidence of aspirin resistance was significantly higher in patients who developed non-fatal coronary events on long term follow-up following elective PCI. Thus, these findings suggest that aspirin resistance might be an important risk factor that could affect the outcome following PCIs.",
author="Catakoglu, Alp B.
and Aytekin, Saide
and Celebi, Huseyin
and Sener, Murat
and Kurtoglu, Hilal
and Demiroglu, Cemsid
and Aytekin, Vedat",
pages="531--538",
url="https://www.termedia.pl/The-influence-of-aspirin-resistance-on-non-fatal-coronary-events-following-percutaneous-coronary-interventions,19,13926,1,1.html"
}