@Article{Hosseinimehr2009,
journal="Archives of Medical Science",
issn="1734-1922",
volume="5",
number="4",
year="2009",
title="Therapeutic and protective effect of oxymetholone against mortality induced by gamma irradiation in mice",
abstract="  Introduction:  Oxymetholone can stimulate bone marrow cells and increase the blood cells in the peripheral blood vessels. Previously we showed that administration of oxymetholone as a single dose increased survival rate in mice against a lethal dose of \γ irradiation. In this study, we determined the percentage survival rate in irradiated mice treated with oxymetholone at divided low dose and prior and after irradiation.   Material and methods:  Oxymetholone at different doses (40, 80, 160 and  320 mg/kg) was administered to mice by gavage with starting time at 24 h before or 1 h after exposure to a lethal dose of \γ irradiation for four consecutive days. Mortality was recorded daily for 30 days. The percentage survival rates were compared with two-sample test for proportions.   Results:  At 30 days after treatment, the percentage of animal survival in each group was between 15 and 25%, compared to 0% in control-irradiated mice. Administration of oxymetholone at a single dose of 640 mg/kg increased survival rate to 40%. Oxymetholone treatment increased survival rate in mice when administered after irradiation at divided low doses.   Conclusions:  Oxymetholone had potential effects on increasing survival rate when administered after \γ irradiation in mice at divided low doses. With the therapeutic effects of oxymetholone, it can be used for reducing mortality induced by \γ irradiation after exposure to irradiation.",
author="Hosseinimehr, Seyed Jalal
and Zakaryaee, Valiallah
and Froughizadeh, Mohsen",
pages="519--522",
url="https://www.termedia.pl/Therapeutic-and-protective-effect-of-oxymetholone-against-mortality-induced-by-gamma-irradiation-in-mice,19,13929,1,1.html"
}