@Article{Stawerski2010,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="9",
number="1",
year="2010",
title="Immunoexpression of proteins related to apoptosis and proliferation in serous ovarian tumour",
abstract="  Introduction:   Ovarian cancer takes fourth place as a cause of death from all cancers and first place from gynaecological malignancies in Poland. Recent investigations have noted the prognostic significance of proteins linked with proliferation (Ki-67) and apoptosis (CAS \– cellular apoptosis susceptibility protein).    The aim  of the study was to evaluate the immunoexpression of CAS and Ki-67 proteins in metastatic and non-metastatic serous ovarian tumours, as well as to find possible relationships between this immunoexpression and tumour proliferation activity.    Material and methods:   The analysis comprised 43 women diagnosed and treated for malignant epithelial ovarian tumours. The immunoexpression of CAS protein was assessed semiquantitatively, whereas immunoexpression of Ki-67 was performed using a computer image analysis system.    Results:   The immunoexpression of both CAS and Ki-67 proteins was significantly increased in the metastatic group as compared with patients without metastases. Also, a positive correlation was found between immunoexpression of Ki-67 and CAS protein, but this correlation was not significant.    Conclusions:   In conclusion, our data suggest that increased immunoexpression of CAS and Ki-67 proteins in serous ovarian tumours may be helpful in identifying cases of higher metastatic potential.",
author="Stawerski, Paweł
and Wągrowska-Danilewicz, Małgorzata
and Stasikowska, Olga
and Danilewicz, Marian",
pages="23--27",
url="https://www.termedia.pl/Immunoexpression-of-proteins-related-to-apoptosis-and-proliferation-in-serous-ovarian-tumour,4,14201,1,1.html"
}