@Article{Sokołowska-Wojdyło2010,
journal="Dermatology Review/Przegląd Dermatologiczny",
issn="0033-2526",
volume="97",
number="2",
year="2010",
title="Dipeptidyl-aminopeptidase IV (CD26) in clinical diagnosis of cutaneous  T cell lymphomas",
abstract=" Introduction. Dipeptidyl-aminopeptidase IV, also known as CD26 antigen, plays a pivotal role in the pathogenesis of cutaneous T-cell lymphomas (CTCL). Nowadays it is believed that the loss of T-cell CD26 expression is a feature of circulating Sezary cells in peripheral blood.   Objective.  Evaluation of the loss of T-cell CD26 expression as a diagnostic and prognostic marker in patients with CTCL and erythrodermias caused by other inflammatory dermatoses.   Material and methods.  T-cell immunophenotyping by flow cytometry in 71 patients with CTCL, including Sezary syndrome, as well as with inflammatory skin diseases.    Results.  High levels of CD4+/CD7\–/CD26\– cells and concomitant low T4:T8 ratio were seen in patients with Sezary syndrome and highly advanced stages of CTCL.   Conclusions.  The loss of CD26 expression evaluated by flow cytometric immunophenotyping seems to be a useful method in dermatological practice for differential diagnosis of cutaneous T-cell lymphomas, especially Sezary syndrome. Probably the loss of T-cell CD26 antigen expression and high levels of Lutzner cells in peripheral blood in patients with inflammatory dermatoses may be a risk factor of CTCL development in future. It requires however further clinical observations.",
author="Sokołowska-Wojdyło, Małgorzata
and Maciejewska-Radomska, Agata
and Barańska-Rybak, Wioletta
and Lewandowski, Andrzej
and Cegielska, Agnieszka
and Roszkiewicz, Jadwiga",
pages="74--78",
url="https://www.termedia.pl/Dipeptidyl-aminopeptidase-IV-CD26-in-clinical-diagnosis-of-cutaneous-T-cell-lymphomas,56,14641,1,1.html"
}