@Article{Abd El Dayerm2010,
journal="Archives of Medical Science",
issn="1734-1922",
volume="6",
number="2",
year="2010",
title="Original researchScreening for coeliac disease among Egyptian children",
abstract=" Introduction:  To screen for coeliac disease in Egyptian children with non-endocrinal short stature, refractory iron deficiency anaemia and type 1 diabetes. Also, to evaluate the sensitivity and specificity of different serological tests for diagnosis of coeliac disease (CD).   Material and methods:  The study included 292 patients with clinical risk of CD. Testing for coeliac antibodies was performed, together with upper gastro­intestinal endoscopy and small intestinal biopsy.   Results:  Eleven patients (44%) among 25 patients with refractory iron deficiency anaemia, 23 patients (34.3%) among 67 patients with non-endocrinal short stature, and 6 patients (3%) among 200 patients with type I diabetes mellitus were diagnosed by jejunal biopsy as having coeliac disease. AGA (IgG) had the highest sensitivity for diagnosing CD (80.0%) followed by the TTG (72.7%) antibody, while ARA had the highest specificity (95.9%) followed by anti-EMA (94.7%).   Conclusions:  Coeliac disease is more common in Egyptian children with refractory iron deficiency anaemia, non-endocrinal short stature and type 1 diabetes than was previously thought; therefore it is mandatory to screen such patients for CD. Serological tests showed fairly good sensitivity and specificity for the diagnosis; however, intestinal biopsy remains the cornerstone for definitive diagnosis of patients with immunological reaction to gluten.",
author="Abd El Dayerm, Soha M.
and Ahmed Aly, Azza
and Abd El Gafar, Esmat
and Kamel, Hesham",
pages="226--235",
doi="10.5114/aoms.2010.13900",
url="http://dx.doi.org/10.5114/aoms.2010.13900"
}