@Article{Parzęcka2010,
journal="Gastroenterology Review/Przegląd Gastroenterologiczny",
issn="1895-5770",
volume="5",
number="3",
year="2010",
title="Influence of Helicobacter pylori genetic type on gastroesophageal acid reflux disease in children and teenagers",
abstract=" Introduction:  The role of Helicobacter pylori (H. pylori) infection in pathogenesis of gastroesophageal reflux disease (GERD) remains controversial. It seems that the genotype of H. pylori influences that dependence.  Aim: To assess the significance of H. pylori genotype in gastroesophageal reflux (GER) in children and teenagers.    Material and methods:  Hundred and one children in whom endoscopy of the upper part of the gastrointestinal tract was performed and H. pylori infection was demonstrated in histopathological and/or urease test and urea breath test. Helicobacter pylori identification was performed using the PCR method to determine the genetic type of CagA and VacA. Triple-drug eradication therapy was introduced. pH-metric examination was performed before and after treatment.    Results:  Infection with type I strain was found in 32.7% of patients, type II in 67.3%. Concerning the group of patients infected with type I H. pylori, GER was found in 57.6% of patients, while 45.6% infected with type II H. pylori suffered from GER. It was induced de novo in 15% of patients in the group of patients infected with type I and in 15% of cases was removed after eradication. Change concerning GER intensity degree did not occur in 70% of patients. Gastroesophageal reflux was induced de novo in the group of patients infected with type II H. pylori in 12.8% of cases and GER was removed after eradication in 12.8%. Change concerning GER intensity degree did not occur in 74.4% of patients. The pH-metry result after treatment was non-diagnostic in 5 patients. These differences were not statistically significant.    Conclusions:  Genetic type of H. pylori did not influence gastroesophageal reflux occurrence or change of gastro­esophageal reflux intensity degree after eradication.",
author="Parzęcka, Monika
and Szaflarska-Popławska, Anna
and Mierzwa, Grażyna
and Gorzkiewicz, Marta
and Łuczak, Sylwia
and Grzybowski, Tomasz
and Czerwionka-Szaflarska, Mieczysława",
pages="151--156",
doi="10.5114/pg.2010.14140",
url="http://dx.doi.org/10.5114/pg.2010.14140"
}