@Article{Armstrong2010,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="48",
number="2",
year="2010",
title="Original articleA spatial pattern analysis of \β-amyloid (A\β) deposition in the temporal lobe in Alzheimer\'s disease",
abstract="To determine the factors influencing the distribution of \-amyloid (A\β) deposits in Alzheimer\’s disease (AD), the spatial patterns of the diffuse, primitive, and classic A\\ deposits were studied from the superior temporal gyrus (STG) to sector CA4 of the hippocampus in six sporadic cases of the disease. In cortical gyri and in the CA sectors of the hippocampus, the A\β deposits were distributed either in clusters 200-6400 \µm in diameter that were regularly distri-buted parallel to the tissue boundary or in larger clusters greater than 6400 \µm in diameter. In some regions, smaller clusters of A\β deposits were aggregated into larger \‘superclusters\’. In many cortical gyri, the density of A\β deposits was positively correlated with distance below the gyral crest. In the majority of regions, clusters of the diffuse, primi-tive, and classic deposits were not spatially correlated with each other. In two cases, double immunolabelled to reveal the A\β deposits and blood vessels, the classic A\β deposits were clustered around the larger diameter vessels. These results suggest a complex pattern of A\β deposition in the temporal lobe in sporadic AD. A regular distribution of A\β deposit clusters may reflect the degeneration of specific cortico-cortical and cortico-hippocampal pathways and the influence of the cerebral blood vessels. Large-scale clustering may reflect the aggregation of deposits in the depths of the sulci and the coalescence of smaller clusters.",
author="Armstrong, Richard A.",
pages="67--74",
url="https://www.termedia.pl/Original-article-A-spatial-pattern-analysis-of-946-amyloid-A-946-deposition-in-the-temporal-lobe-in-Alzheimer-s-disease,20,15059,1,1.html"
}