@Article{Ahmed2010,
journal="Archives of Medical Science",
issn="1734-1922",
volume="6",
number="4",
year="2010",
title="Clinical researchRed cell alloimmunization and autoantibodies in Egyptian transfusion-dependent thalassaemia patients",
abstract=" Introduction:   The objective of this study was to explore the frequency of red cell alloantibodies and autoantibodies among -thalassaemia patients who received regular transfusions.   Material and methods:   This study included 501 patients with -thalassaemia. This work planned to study the presence of alloantibodies and autoantibodies to different red cell antigens in multitransfused thalassaemia patients using the ID. Card micro typing system.    Results:   Of a total of 501 -thalassaemia patients included in the study, 11.3% of patients developed alloantibodies; 9.7% of these alloantibodies were clinically significant. The most common alloantibodies were anti-K, anti-E and anti-C. The rate of incidence of these alloantibodies was 3.9%, 3.3% and 1.7% respectively. Autoantibodies occurred in 28.8% of the patients and 22.1% of these antibodies were typed IgG. There was a significant association between splenectomy with alloimmunization and autoantibody formation (p = 0.03, p = 0.001 respectively). There was no significant association between alloantibody, autoantibody formation and number of transfused packed red cells.    Conclusions:   Alloimmunization to minor erythrocyte antigens and erythrocyte autoantibodies of variable clinical significance are frequent findings in transfused -thalassaemia patients. There is an association between absence of the spleen and the presence of alloimmunization and autoantibody formation.",
author="Ahmed, Azza Mohamed
and Hasan, Nehal Salah
and Hassan Ragab, Shadia
and Habib, Sonia Adolf
and Emara, Nahed Abdelmonem
and Ahmed Aly, Azza",
pages="592--598",
doi="10.5114/aoms.2010.14473",
url="http://dx.doi.org/10.5114/aoms.2010.14473"
}