@Article{Stepulak2010,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="14",
number="5",
year="2010",
title="The role of ionotropic glutamate receptors in cancer biology",
abstract="Effective treatment of different types of cancer is limited with regard to the clinical stage of the disease and/or bio­logical properties of the tumour. Be­cause of the low efficacy of traditional chemotherapy, new types of targeted therapy acting selectively on specific metabolic pathways pathologically deregulated in cancer cells are still needed. In the last decade glutamate signalling has emerged as a new potential therapeutic target in cancer. This review outlines the role of gluta­mate as a growth factor for cancer cells, the presence and function of ionotropic glutamate receptors in cancers, and the potential impact of glutamate receptor antagonists as a new generation of cyto­statics. The review also describes suggested mechanisms of their activity at the molecular level.",
author="Stepulak, Andrzej
and Polberg, Krzysztof
and Kupisz, Krzysztof
and Jarząb, Agata
and Grabarska, Aneta
and Jeleniewicz, Witold
and Kiełbus, Michał
and Stryjecka-Zimmer, Marta",
pages="291--296",
doi="10.5114/wo.2010.17291",
url="http://dx.doi.org/10.5114/wo.2010.17291"
}