@Article{Terlikowska-Brzósko2010,
journal="Dermatology Review/Przegląd Dermatologiczny",
issn="0033-2526",
volume="97",
number="6",
year="2010",
title="Two cases of scleromyxedema",
abstract="  Introduction  . Scleromyxedema is a chronic disease numbered among mucinoses. Diagnostic criteria are: characteristic scleroderma-like skin lesions, monoclonal gammopathy without thyroid gland dysfunction, and, in histopathological examination, fibroblast proliferation and mucin deposits in the extracellular matrix.       Objective  . To present 2 cases of scleromyxedema with different types of skin lesions predominating.      Case report  . Two cases of scleromyxedema with different clinical manifestations are presented. In the first patient a scleroderma-like lesion predominated, while in the second one papular eruption was mainly observed. Each patient had individualized therapy; however, neither prednisone combined with chlorambucil and pulses with cyclophosphamide and prednisone in the first patient nor melphalan pulses in the second one were sufficiently effective.      Conclusions  . Regardless of the clinical presentation, management of scleromyxedema can be challenging because of limited efficacy, safety or accessibility of different recommended treatment modalities.",
author="Terlikowska-Brzósko, Agnieszka
and Kwiek, Bartłomiej
and Glińska, Olga
and Kozłowska, Anna
and Błaszczyk, Maria
and Dwilewicz-Trojaczek, Jadwiga
and Sachs, Wojciech",
pages="378--385",
url="https://www.termedia.pl/Two-cases-of-scleromyxedema,56,16040,1,1.html"
}