@Article{Gutkowski2010,
journal="Central European Journal of\ Immunology",
issn="1426-3912",
volume="35",
number="4",
year="2010",
title="Clinical immunology
Effect of orally administered probiotic strains Lactobacillus and Bifidobacterium in children with atopic asthma",
abstract="Children with mild to moderate asthma (n = 46), aged 4-10 years, were randomly allocated into groups matched according to age, height and body weight (Group 1 and Group 2). Group 1 (n = 22) received Trilac capsules (1.6 × 109 lactic acid bacteria cells: Lactobacillus acidophilus – 37.5%, Bifidobacterium bifidum – 37.5% and Lactobacillus delbrueckii subsp. bulgaricus – 25%), whilst Group 2 (n = 24) received   placebo  . The study was performed over 12 weeks and the results were evaluated using lung function and immunological tests. During the study period, the patients continued treatment with inhaled beta-mimetics and inhaled corticosteroids.   The children receiving Trilac significantly improved their lung function and presented with less episodes of asthma exacerbations during the study period than the children receiving   placebo  . Similarly, the amount of bronchodilatators used was significantly reduced in the children receiving Trilac than the children on   placebo  . The differences were also observed in the immunological parameters studied by flow cytometry. The statistically significant increase in the expression of HLA-DR on monocytes and decrease of CD8CD45RA+ lymphocytes were observed in Trilac group, but not in the   placebo   group. The levels of IFN- (Th1) and IL-10 (Treg) cytokines were increased in both examined groups.   In conclusion, a positive effect of 12-weeks administration of Trilac on the clinical course and lung function of the children with mild to moderate asthma was observed. Changes of immunological markers (increase of HLA-DR expression and decrease of CD8CD45RA+ cells) in the children treated with Trilac were also noted.",
author="Gutkowski, Piotr
and Madaliński, Kazimierz
and Grek, Martyna
and Dmeńska, Hanna
and Syczewska, Małgorzata
and Michałkiewicz, Jacek",
url="https://www.termedia.pl/Clinical-immunology-Effect-of-orally-administered-probiotic-strains-Lactobacillus-and-Bifidobacterium-in-children-with-atopic-asthma,10,16116,1,1.html"
}