@Article{Romanowicz2011,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="10",
number="1",
year="2011",
title="The single nucleotide polymorphism (SNP) in DNA repair genes by homologous recombination 
(XRCC2 and RAD51) and the risk of sporadic breast cancer in Poland",
abstract="  Background  : Single nucleotide polymorphisms in the DNA repair genes have been extensively studied in association with various human cancers such as breast cancer.     Material and methods  : We investigated an association of polymorphisms in the DNA repair genes   XRCC2-Arg188His and RAD51-135G/C with the breast cancer risk. Genotypes were analysed by PCR-RFLP assays in 80 patients with breast cancer and 80 controls.     Results  : The distribution of the genotypes of XRCC2 Arg188His in both controls and patients did not differ significantly (p > 0,05) from those predicted by the Hardy-Weinberg distribution. The C/C genotype of RAD51 increased the risk of breast cancer occurrence (OR 2.29; 95% PU (0.91–5.72), p = 0.04).     Conclusion  : G135C polymorphism of the RAD51 gene may be associated with the incidence of sporadic breast cancer in Polish women.",
author="Romanowicz, Hanna
and Smolarz, Beata
and Baszczyński, Jakub
and Zadrożny, Marek
and Kulig, Andrzej
and Góralczyk, Bożena
and Połać, Ireneusz
and Pertyński, Tomasz",
pages="10--14",
url="https://www.termedia.pl/The-single-nucleotide-polymorphism-SNP-in-DNA-repair-genes-by-homologous-recombination-r-n-XRCC2-and-RAD51-and-the-risk-of-sporadic-breast-cancer-in-Poland,4,16339,1,1.html"
}