@Article{Lesiak2011,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="28",
number="2",
year="2011",
title="Original PaperThe influence of phototherapy with narrow band UVB on 25-hydroxycholecalciferol serum concentration in psoriasis vulgaris patients",
abstract="  Introduction  : Narrow band UVB (311-313 nm) is commonly used in the treatment of many skin diseases, including psoriasis vulgaris. Under skin exposure to UVB synthesis of vitamin D occurs.     Aim  : The aim of the study was to assess the serum concentration of vitamin D in psoriasis vulgaris as well as the changes in 25-hydroxycholecalciferol (25(OH)D) and parathormone (PTH) serum level under a series of UVB exposures. Additionally, we checked the correlation between the final vitamin D concentration and cumulative NB-UVB dose.     Material and methods  : The study group included 47 patients with psoriasis vulgaris in the age range 20-65 years old. The patients were treated with 20 NB-UVB exposures. In each patient, 25(OH)D (RIA – radioimmunoassay) and PTH (immunochemiluminescence assay) serum concentration was checked 3 times: before therapy, and after 10 and 20 exposures.     Results  : Baseline vitamin D concentration was 26.5 ng/ml. After the first 10 NB-UVB exposures vitamin D serum concentration statistically increased to the value of 38 ng/ml (p   0.05). A PTH serum concentration did not statistically change during the whole therapy. A positive correlation between the cumulative NB-UVB dose and the final 25(OH)D serum concentration was observed (p < 0.05).     Conclusions  : Deficiency of vitamin D serum level is observed in psoriatic patients. NB-UVB significantly increases 25(OH)D synthesis dependently on cumulative dose, with no effect on PTH serum level. The lower increase in the vitamin D level in the course of phototherapy testifies to the photoadaptation phenomenon.",
author="Lesiak, Aleksandra
and Brucka-Stempkowska, Anna
and Kubik, Dagmara
and Słowik-Kwiatkowska, Iwona
and Rogowski-Tylman, Michał
and Sysa-Jędrzejowska, Anna
and Narbutt, Joanna",
pages="97--102",
url="https://www.termedia.pl/Original-Paper-The-influence-of-phototherapy-with-narrow-band-UVB-on-25-hydroxycholecalciferol-serum-concentration-in-psoriasis-vulgaris-patients,7,16626,1,1.html"
}