@Article{Łoś-Rychalska2011,
journal="Gastroenterology Review/Przegląd Gastroenterologiczny",
issn="1895-5770",
volume="6",
number="3",
year="2011",
title="Does a relationship of HLA B alleles with course of hepatitis C virus infection in children and youth and efficacy of its treatment exist?",
abstract="  Introduction:  The course of HCV infection and prognosis for its treatment depend not only on virus factors (e.g. genotype) but also of host lying, as genetic conditions. A particular role is attributed to major histocompatibility complex genes.   Aim:  To estimate the relationship of HLA B alleles with alanine transferase activity (ALT) as expression of the course of infection and attempt to estimate the relationship of the alleles with efficiency of antiviral treatment.   Material and methods:  The study included 61 patients with persistent viral hepatitis type C, aged 5-18 years, 51 treated (42 with interferon and ribavirin) and 10 not treated. Among treated patients, 31 did not respond and in 20 a sustained virological response was obtained. In all patients HLA typing was performed (HLA PCR-SSP method, low and next high resolutions). Frequency of particular HLA B alleles was compared among groups of patients (with correct and increased ALT activity, responders and non-responders for antiviral treatment).    Results:  In the analysis of the influence of HLA B alleles on ALT activity in the course of HCV infection a significant dependence was not ascertained. Analysing early and sustained response to antiviral treatment significant dependence was not ascertained either.   Conclusions:  The results do not confirm associations between HLA B alleles and ALT activity in the course of HCV infection nor between these alleles and efficiency of antiviral treatment. Due to the fact that multiplicity of HLA B alleles exists, considering some indispensable insignificant differences, it is necessary to perform a study on a larger group of patients.",
author="Łoś-Rychalska, Ewa
and Czerwionka-Szaflarska, Mieczysława
and Szaflarska-Popławska, Anna",
pages="160--169",
doi="10.5114/pg.2011.22801",
url="http://dx.doi.org/10.5114/pg.2011.22801"
}