@Article{Mękal2011,
journal="Central European Journal of\ Immunology",
issn="1426-3912",
volume="36",
number="2",
year="2011",
title="Review paperNatural TH2 (nTH2) cells, interleukin 36 and interleukin 37 – new elements of innate immunity",
abstract="  This paper presents new elements of innate immunity, such as recently described natural T H 2 cells (nT H 2 or NHC), interleukin 36 (IL-36) and IL-37. nT H 2 cells are located in structures defined as fat-associated lymphoid clusters (FALC), and their role is principally associated with the production of cytokines that are characteristic for T H 2 lymphocytes participating in the course of allergic processes and in host defence during invasions of various parasites. The expression of IL-36 was mainly recorded in the thymus, testis and uterus cells. This interleukin indicates suppressive effect on innate immunity, principally by inhibition of pro-inflammatory cytokine production, as well as by creation of an active complex with signalling protein – Smad3 and cooperation with TGF-β. In turn, IL-37 is synthesized in the same places as IL-36, and additionally in macrophages and epithelial cells. It is also considered as an inhibitor of innate immunity.  ",
author="Mękal, Agata
and Trzeciak-Ryczek, Alicja
and Tokarz-Deptuła, Beata
and Deptuła, Wiesław",
pages="113--116",
url="https://www.termedia.pl/-Review-paper-Natural-T-H-2-nT-H-2-cells-interleukin-36-and-interleukin-37-new-elements-of-innate-immunity,10,16865,1,1.html"
}