@Article{Kolanko2011,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="28",
number="3",
year="2011",
title="Review paperVitamin D and its receptor – role and activity in the human body. Anomalies of metabolism and structure associated with psoriasis",
abstract="Psoriasis is a common, chronic and recurrent inflammatory dermatosis with abnormally exaggerated epidermal cellular turnover, which affects about 2.5% of the world’s population. One of the therapeutic modalities for the treatment of moderate skin lesions is phototherapy with NB-UVB radiation (311 nm). The 290-315 nm UV radiation produces in the epidermis vitamin D of 7-dehydrocholesterol which is then hydroxylated into 25(OH)D and 1,25(OH)2D. Active metabolites of vitamin D, apart from regulating calcium-phosphorus homeostasis, have been shown to inhibit hyperproliferation and to induce terminal differentiation of cultured human keratinocytes through their action on the genome by the nuclear receptor VDR (vitamin D receptor). The literature includes many studies on VDR gene polymorphism and abnormal vitamin D metabolism in some patients with psoriasis. These anomalies could be possibly connected to adverse reactions to NB-UVB and treatment with vitamin D analogues.",
author="Kolanko, Magdalena
and Brzezińska-Wcisło, Ligia",
pages="212--216",
url="https://www.termedia.pl/Review-paper-Vitamin-D-and-its-receptor-role-and-activity-in-the-human-body-Anomalies-of-metabolism-and-structure-associated-with-psoriasis,7,16939,1,1.html"
}