@Article{Romanowicz-Makowska2011,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="10",
number="3",
year="2011",
title="The role of single nucleotide polymorphism Arg399Gln XRCC1 gene in endometrial cancer 
in Polish postmenopausal women",
abstract="  Background:   Endometrial cancer is one of the most common malignant neoplasms which appear in the uterine body. X-ray repair cross-complementing 1 (XRCC1) protein can be involved in the repair of DNA lesions, which are known to contribute to endometrial cancer.     Material and methods  : The genotype analysis of XRCC1 Arg399Gln gene polymorphisms for 456 endometrial cancer patients and 300 controls of cancer-free subjects in the Polish population was performed using PCR-based restriction fragment length polymorphism (PCR-RFLP).     Results  : An association was found between endometrial cancer occurrence and the Gln/Gln genotype of the Arg399Gln polymorphism (odds ratio 2.22; 95% confidence interval 1.51-3.27, p < 0.0001). The Gln/Gln genotype of XRCC1 increased the risk of type I endometrial cancer occurrence (OR = 2.13, 95% CI = 2.02-2.75, p < 0.012).   No statistically significant association was found between gene polymorphisms and endometrial cancer risk factors such as BMI, HRT, uterine bleeding, diabetes and hypertension.    Conclusion  : The results support the hypothesis that the Arg399Gln polymorphism of the XRCC1 gene may be associated with the development of sporadic endometrial cancer in Polish women.",
author="Romanowicz-Makowska, Hanna
and Smolarz, Beata
and Houli, Amer
and Góralczyk, Bożena
and Połać, Ireneusz
and Szyłło, Krzysztof",
pages="191--196",
url="https://www.termedia.pl/The-role-of-single-nucleotide-polymorphism-Arg399Gln-XRCC1-gene-in-endometrial-cancer-r-nin-Polish-postmenopausal-women,4,16947,1,1.html"
}