@Article{Romanowicz-Makowska2011,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="62",
number="2",
year="2011",
title="Single nucleotide polymorphism in DNA base excision repair genes XRCC1 and hOGG1 and the risk of endometrial carcinoma in the Polish population",
abstract="  Background  : Polymorphisms in the human oxoguanine glycosylase 1 (  hOGG1  ) and X-ray repair cross-complementing 1 (  XRCC1  ) genes have been extensively studied in the association with various human cancers such as endometrial cancer.      Material and methods  : The genotype analysis of   hOGG1   Ser326Cys and   XRCC1   Arg399Gln gene polymorphisms for 150 endometrial cancer patients and 150 controls of cancer-free subjects, in the Polish population, were performed using PCR-based restriction fragment length polymorphism (PCR-RFLP).      Results  : Although there were no significant (p > 0.05) differences in the frequencies of genotypes or alleles of   hOGG1   genes between patients and controls, the frequency of the   XRCC1   399Gln allele was significantly greater in endometrial cancer patients compared with controls (p = 0.033) with an odds ratio of 1.39 (95% confidence interval 0.99 to 1.95). The distributions of genotypes and alleles of the genes   hOGG1   and   XRCC1   were not significantly associated with different grades of endometrial cancer (p > 0.05).     Conclusion  : In conclusion, these findings indicated that   XRCC1   Arg399Gln polymorphism may be a genetic determinant for developing endometrial cancer. The   hOGG1   Ser326Cys may not play an important role in susceptibility to endometrial cancer in Polish women.",
author="Romanowicz-Makowska, Hanna
and Smolarz, Beata
and Houli, Amer
and Szyłło, Krzysztof",
pages="89--94",
url="https://www.termedia.pl/Single-nucleotide-polymorphism-in-DNA-base-excision-repair-genes-XRCC1-and-hOGG1-and-the-risk-of-endometrial-carcinoma-in-the-Polish-population,55,17110,1,1.html"
}