@Article{Frankiewicz2011,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="10",
number="4",
year="2011",
title="Vitamin D supplementation – is it only osteoprotection?",
abstract="Non-classical effects of Vitamin D (cholecalcipherol), related to its immunomodulating and antiproliferative activity have been known for 25 years. However, only recent years brought a better understanding of how these non-classical effects of cholecalcipherol influence patophysiology and prevention of many diseases. Review of scientific reports on vitamin D point out to three fundamental facts: 1) numerous population data prompt a reinterpretation of our understanding of physiological levels of Vitamin D and raise awareness of vitamin D deficiency becoming a global problem, 2) epidemiological data linked a vitamin D deficiency with a higher susceptibility to many diseases and increased mortality, 3) a much wider than previously considered existence of vitamin D receptors and an extra-renal, biochemical machinery capable of synthesizing an active form of vitamin D - 1,25-(OH)2-D3, (including lymphoid tissue, CNS, pancreas, parathyroid gland etc.). All this suggest that so called extra-skeletal function of vitamin D and its physiological impact may play an important role in human physiology, extending far beyond the skeletal and calcium homeostasis. In light of an accumulating evidence, appropriate supplementation of vitamin D (which seems to be higher than most of current recommendations) could lower or even prevent the prevalence of various clinical disorders.",
author="Frankiewicz, Tadeusz",
pages="328--333",
url="https://www.termedia.pl/-Vitamin-D-supplementation-is-it-only-osteoprotection-,4,17214,1,1.html"
}