@Article{Trzeciak2011,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="28",
number="4",
year="2011",
title="Review paper
Interleukin 18 – a pleiotropic cytokine involved in the Th1 and Th2 immunological response",
abstract="Interleukin 18 (IL-18) is a pleiotropic cytokine that plays a crucial role in the control of the balance between the Th1 and Th2 response. Synergistically with IL-12, IL-18 promotes an immunological response of the TH1 type, by enhancing INF-γ synthesis and inhibition of IgE production. On the other hand, IL-18 can enhance IL-4 and IL-13 production and stimulates IgE synthesis. Moreover, in the presence of IL-3, IL-18 can directly stimulate basophils and mast cells to produce their mediators. The gene of IL-18 is located on chromosome 11q22.2-22.3, which was identified as an important candidate region for susceptibility to atopy. The aim of this paper is to characterize IL-18, the evolution of views on it and to emphasize the influence of IL-18 on the development of infectious, inflammatory, autoimmune diseases and malignancies with a special consideration of atopic diseases.",
author="Trzeciak, Magdalena
and Sokołowska-Wojdyło, Małgorzata
and Barańska-Rybak, Wioletta
and Maciejewska, Agata
and Michajłowski, Igor
and Roszkiewicz, Jadwiga",
pages="309--312",
url="https://www.termedia.pl/Review-paper-r-nInterleukin-18-a-pleiotropic-cytokine-involved-in-the-Th1-and-Th2-immunological-response,7,17259,1,1.html"
}