@Article{Szczerkowska-Dobosz2011,
journal="Dermatology Review/Przegląd Dermatologiczny",
issn="0033-2526",
volume="98",
number="5",
year="2011",
title="Genetics of psoriasis – from serological studies of human leukocyte antigens to whole genome
association studies",
abstract="Psoriasis is a complex disease with multifactorial mode of inheritance, which means that its clinical manifestations depend upon multiple genes interacting with environmental agents. The major genetic factor responsible for 35-50% susceptibility for early psoriasis in the Caucasian population,  HLA-Cw*06 , is located within the major histocompatibility complex (MHC) on the sixth chromosome. Whole genome association studies, the newest research trend, revealed three genetic, non-MHC related pathways connected with psoriasis susceptibility: Th17, Th2 and NF-kB-dependent. These genes are responsible for inflammation, epidermal proliferation and epidermal barrier function in psoriasis.",
author="Szczerkowska-Dobosz, Aneta
and Rębała, Krzysztof",
pages="377--383",
url="https://www.termedia.pl/Genetics-of-psoriasis-from-serological-studies-of-human-leukocyte-antigens-to-whole-genome-r-nassociation-studies-,56,17698,1,1.html"
}