@Article{Kamer2011,
journal="Gastroenterology Review/Przegląd Gastroenterologiczny",
issn="1895-5770",
volume="6",
number="6",
year="2011",
title="TLR4 receptor and selected cytokines in development of food allergy in infants and small children",
abstract=" Introduction  : Food allergy (FA) in infants and small children is an important and rising problem. TLR4 is the main receptor recognizing lipopolysaccharide (LPS) and belonging to the Toll-like receptor (TLR) family. Triggering this receptor leads to activation of nuclear factor κB (NF-κB) and interferon regulatory factors (IRFs) and expression of genes included in immunological reactions.     Material and methods  : Fifty children (aged 1-36 months) were included in this study: 35 children with food allergy (17 of them with IgE-dependent allergy, 18 with IgE-independent allergy) and 15 healthy children without any allergy. In this work mRNA expression of TLR4 receptor on neutrophils and concentrations of selected Th1/Th2 cytokines were evaluated.     Results  : We observed lower mRNA TLR4 expression in children with food allergy especially IgE-independent food allergy. Furthermore, higher concentrations of IL-4, IL-5 and IL-10 in children with food allergy compared with children from the control group were found. Estimated mRNA expression of TLR4 on neutrophil surfaces was negatively correlated with serum concentration of IL-4 and positively correlated with IFN-γ serum levels in children with IgE-dependent FA.     Conclusions:   Results of this study suggest a role of innate immunity in the development of food allergy and evaluation of this immunity can be helpful in diagnosis of allergy in small children. Streszczenie",
author="Kamer, Barbara
and Kulig, Karolina
and Lewkowicz, Przemysław
and Głowacka, Ewa
and Sasiak, Andrzej
and Tchórzewski, Henryk",
pages="370--375",
doi="10.5114/pg.2011.25992",
url="http://dx.doi.org/10.5114/pg.2011.25992"
}