@Article{Samulak2012,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="11",
number="1",
year="2012",
title="Association between single nucleotide polymorphisms of the DNA mismatch repair gene hMSH2 
and postmenopausal breast cancer in Polish women",
abstract="  Background  : Mutations in the   hMSH2   gene predispose to a number of tumorigenic conditions, including breast cancer. hMSH2 encodes a protein in the mismatch repair (MMR) pathway which is involved in the removal of mispairs originating during replication or from damaged DNA.     Material and methods  : The genotype analysis of Gly322Asp and Asn127Ser   hMSH2   gene polymorphisms for 205 breast cancer patients and 180 controls of cancer-free subjects in the Polish population was performed using the PCR-based restriction fragment length polymorphism (PCR-RFLP).     Results  : The distribution of genotypes of the Gly322Asp polymorphism of   hMSH2   in patients differed significantly (p < 0.05) from those predicted by the Hardy-Weinberg equilibrium. There were significant differences in the frequencies of alleles between breast cancer subjects and controls (p < 0.05). The Asp/Asp genotype of   hMSH2   increased the risk of breast cancer occurrence (OR 2.60, 95% CI 1.03-6.53, p = 0.043).     Conclusion  : The results support the hypothesis that the Gly322Asp polymorphism of the hMSH2 gene may be associated with the incidence of sporadic breast cancer in Polish women.",
author="Samulak, Dariusz
and Romanowicz-Makowska, Hanna
and Smolarz, Beata
and Połać, Ireneusz
and Zadrożny, Marek
and Westfal, Bogusław
and Sporny, Stanisław",
pages="9--13",
url="https://www.termedia.pl/-Association-between-single-nucleotide-polymorphisms-of-the-DNA-mismatch-repair-gene-hMSH2-r-n-and-postmenopausal-breast-cancer-in-Polish-women-,4,18233,1,1.html"
}