@Article{Pinarli2012,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="16",
number="1",
year="2012",
title="Institutional experience of paediatric high-grade central nervous system  tumours: An analysis of 74 patients and review of the literature",
abstract="  Aim of the study:   Although the survival for children with certain central nervous system (CNS) tumour types has improved through current surgical and adjuvant treatment modalities, the prognosis of many high-grade tumours remains poor despite aggressive treatment. The aim of this study is to analyse patients with high-grade brain tumours in our institution to determine the histopathology, clinical characteristics, treatment modalities, and survival.      Material and methods  : A total of 74 patients with a diagnosis of high-grade brain tumour were analysed. There were a total of 31 patients with embryonal tumours, 27 patients with high-grade glial tumours, 12 patients with brain stem gliomas and 4 patients with other high-grade brain tumours.     Results  : There were 48 (65%) boys and 26 (35%) girls (ratio: 1.85) with a median age of 99.7 months (range = 2-204 months). The median follow-up period was 19 months (range = 1-204 months). Tumour recurrence was observed in 38 patients (51.4%). The overall survival rate and event-free survival rate of our patients were 27% and 19.5%, respectively.      Conclusions  : Pediatric high-grade CNS tumours have a very aggressive behaviour and a significant number of children eventually succumb to disease despite multimodal treatment. There is a need of more effective therapeutic approaches for these tumours with poor prognosis. The future improvement in childhood high-grade brain tumour management depends on a better understanding of the molecular genetics and biology of brain tumours.",
author="Pinarli, Faruk Guclu
and Oguz, Aynur
and Karadeniz, Ceyda
and Okur, Arzu
and Sarac, Avni
and Baykaner, Kemali
and Bora, Huseyin
and Poyraz, Aylar",
pages="26--33",
doi="10.5114/wo.2012.27333",
url="http://dx.doi.org/10.5114/wo.2012.27333"
}