@Article{Huang2012,
journal="Central European Journal of\ Immunology",
issn="1426-3912",
volume="37",
number="1",
year="2012",
title="Experimental immunologyAnti-Toll-like receptor 2 antibody, T2.1,
reduces tumor necrosis factor α and
interleukin-6 release and inhibits nuclear
factor κB expression in bacterial lipoprotein
stimulated THP-1 cells",
abstract=" This study analyzed the effects of a blocking anti-Toll-like receptor 2 (TLR2) antibody (T2.1) on TLR2 signaling and inflammatory cytokine production by bacterial lipoprotein (BLP) stimulated THP-1 cells. Cells were treated sequentially with anti-TLR2 antibody and BLP (A + B) or in the reverse order (B + A), or directly stimulated with BLP (B). Blank and isotype control groups were included. Tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) concentrations were measured by ELISA. Expression of nuclear factor κB (NF-κB), TLR2 and myeloid differentiation factor 88 (MyD88) was analyzed by Western Blot. Significantly higher expression of TNF-α, IL-6 and NF-κB was detected in all groups compared with the blank control (P   0.05). However, no significant differences were detected in TLR2 and MyD88 expression among these groups (P > 0.05). These data demonstrated that anti-TLR2 antibody significantly reduced TNF-α, IL-6 and NF-κB expression by BLP-stimulated THP-1 cells, thus indicating the protective value of this antibody  in vivo . ",
author="Huang, Min
and Zhou, Jing
and Bi, Liqing
and Zhang, Qian
and Zhou, Suming",
pages="6--10",
url="https://www.termedia.pl/-Experimental-immunology-Anti-Toll-like-receptor-2-antibody-T2-1-r-nreduces-tumor-necrosis-factor-and-r-ninterleukin-6-release-and-inhibits-nuclear-r-nfactor-B-expression-in-bacterial-lipoprotein-r-ns,10,18370,1,1.html"
}