@Article{Liberski2012,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="50",
number="1",
year="2012",
title="Review article

Prion protein (PrP) deposits in the tectum of experimental Gerstmann-Sträussler-Scheinker disease following intraocular inoculation",
abstract=" The abnormal misfolded isoform of prion protein (PrP d ; “d” for disease) is considered as a surrogate marker for infectivity in the transmissible spongiform encephalopathies (TSEs) or prion diseases, including Creutzfeldt-Jakob disease (CJD). In this experiment, we used intraocular inoculation to study PrP d  deposition in the visual system of the brain of mice infected with the Fujisaki (K.Fu) strain of Gerstmann-Sträussler-Scheinker (GSS) disease. We report here that PrP d  is deposited in the superior colliculus following contralateral intraocular inoculation and thus follows neuronal connections when it spreads into the brain. Until 26 weeks postinoculation, no PrP d -specific immunostaining was observed in the brain. At 27 weeks postinoculation, PrP d  targeted to the contralateral superior colliculus as delicate granular synaptic deposits located in the superficial part of this structure. As already reported, a few spongiform vacuoles were visible in the same area by conventional H\&E staining. In several other sections, vacuoles were visible but no PrPd staining could be detected. ",
author="Liberski, Pawel P.
and Hainfellner, Johannes A.
and Sikorska, Beata
and Budka, Herbert",
pages="85--88",
url="https://www.termedia.pl/Review-article-r-n-r-nPrion-protein-PrP-deposits-in-the-tectum-of-experimental-Gerstmann-Straussler-Scheinker-disease-following-intraocular-inoculation,20,18393,1,1.html"
}