@Article{Cynkier2012,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="63",
number="1",
year="2012",
title="Expression of selected neuropeptides in pathogenesis of bullous pemphigoid and dermatitis herpetiformis",
abstract="Bullous pemphigoid (BP) and dermatitis herpetiformis (DH) are chronic subepidermal bullous diseases, which progress together with an itch and an inflammatory reaction. These symptoms may be the cause of a phenomenon described in the literature as a neurogenic skin inflammation. Neuropeptides are one of the mediators which take part in this process. The aim of our study was to indicate the expression of selected neuropeptides – CRF (corticotropin releasing factor), CGRP (calcitonin gene-related peptide), NKB (neurokinin B), SP (substance P) and the receptor for endothelin B (ETRB) – in the skin of patients suffering from BP or DH. A significantly increased expression of CRF was found in the specimen collected from the skin lesions of patients with BP and DH as well as a significantly increased expression of receptor for endothelin B in the patients with DH by the immunohistochemical method. The results obtained give evidence of a possible participation of CRF and receptor for endothelin B in the pathogenesis of the itch in the dermatitis herpetiformis as well as CRF in bullous pemphigoid.",
author="Cynkier, Anna
and Żebrowska, Agnieszka
and Wągrowska-Danilewicz, Małgorzata
and Danilewicz, Marian
and Erkiert-Polguj, Anna
and Stasikowska-Kanicka, Olga
and Sysa-Jędrzejowska, Anna
and Waszczykowska, Elżbieta",
pages="31--39",
url="https://www.termedia.pl/Expression-of-selected-neuropeptides-in-pathogenesis-of-bullous-pemphigoid-and-dermatitis-herpetiformis,55,18480,1,1.html"
}