@Article{Lin2012,
journal="Archives of Medical Science",
issn="1734-1922",
volume="8",
number="3",
year="2012",
title="Clinical researchA pilot study of circulating PPAR-γ receptor protein in elderly patients with atrial fibrillation",
abstract=" Introduction:  The present study aimed to investigate the relationship between serum peroxisome proliferator-activated receptor- γ (PPAR-γ) protein concentration and inflammatory markers in elderly patients with atrial fibrillation (AF).   Material and methods:  We enrolled a total of 73 elderly patients: 45 with AF as the test group and 28 in sinus rhythm as a control group. We assayed serum PPAR-γ receptor protein, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumour necrosis factor-a (TNF-α). The study protocol and written informed consent were approved by the Ethics Committee of Clinical Research, Peking University First Hospital.   Results : The concentration of PPAR- γ receptor protein was lower in AF patients than that in the control group (p < 0.01), and the concentrations of hs-CRP, IL-6, and TNF-α were higher than those in the control group (all p < 0.01). The PPAR-γ level was negatively correlated with hs-CRP, IL-6, and left atrium diameter (LAD) level (all p < 0.05). On logistic regression analysis, PPAR-γ, hs-CRP, TNF-α and LAD level were associated with AF.    Conclusions : Elderly patients with AF show an inflammatory state and atrial remodeling. The PPAR-γ receptor protein concentration is inversely linked with inflammation in AF. As an important transcription factor regulating inflammatory gene expression, PPAR-γ may take part in the pathogenesis of AF.",
author="Lin, Qing
and Jia, Lina
and Sun, Yanshu",
pages="471--476",
doi="10.5114/aoms.2012.29263",
url="http://dx.doi.org/10.5114/aoms.2012.29263"
}