@Article{Kopińska2012,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="16",
number="3",
year="2012",
title="Rituximab is highly effective for pure red cell aplasia  	and post-transplant lymphoproliferative disorder after unrelated  	hematopoietic stem cell transplantation",
abstract="Pure red cell aplasia (PRCA) and post-transplant lymphoproliferative disorder (PTLD) constitute rare complications after allogeneic hematopoietic stem cell transplantation (AlloHSCT). The incidence of EBV-PTLD is above 1%, but it may increase in patients with well-known risk factors such as EBV seronegativity at the time of transplantation,   T-cell depletion of donor grafts, HLA mismatch and use of antithymocyte globulin (ATG) for prophylaxis of graft     versus   host disease. The risk factors for PRCA were defined and they include:   1) elevated post-transplant anti-donor   isohemagglutinin titers, 2) reduced-in-  ten­sity conditioning before transplant,   3) the presence of anti-A agglutinin and 4) ciclo­sporin for graft   versus   host disease (GVHD) prophylaxis and 5) trans­plant from sibling donor. The anti-CD20 monoclonal antibody rituximab remains the first line treatment for PTLD following AlloHSCT, but its efficacy in PRCA is limited. Reduction of immunosuppression is also strongly advised. This is the first report on an adult patient who simultaneously developed PRCA and PTLD after ABO-mismatched AlloHSCT. The early introduction of rituximab resulted in prompt resolution of clinical symptoms with subsequent full recovery.",
author="Kopińska, Anna
and Helbig, Grzegorz
and Frankiewicz, Andrzej
and Grygoruk-Wiśniowska, Iwona
and Kyrcz-Krzemień, Sławomira",
pages="215--217",
doi="10.5114/wo.2012.29287",
url="http://dx.doi.org/10.5114/wo.2012.29287"
}