@Article{Zhao2012,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="50",
number="2",
year="2012",
title="Original articleDifferential expression of MMP-9 and AQP4 in human
glioma samples",
abstract="  Background : Metalloproteinase-9 (MMP-9) and aquaporin-4 (AQP4) have been individually reported in glioma development. Here, we co-analyzed their expression in multiple forms of human glioma tissues graded from II to IV.    Material and methods : Levels of MMP-9 and AQP4 were evaluated on 50 resected human glioma tissues using immunohistochemistry. Protein levels of both molecules were evaluated by a staining score system based on the percentage of positive cells/staining degree in each dot section. The transwell method was also used to discriminate fast migrating cells and slow migrating cells, in which expression of both MMP-9 and AQP4 was investigated by using immunofluorescence.    Results : The staining score of MMP-9 displayed a positively tumor grade dependent manner, whereas AQP4 expression showed a negatively tumor grade dependent manner. The nuclear translocation of both molecules was observed in astrocytomas with glioblastoma transition, or glioblastoma tissues. Fast migrating cells contain more AQP4, whereas more MMP-9 was localized in slow migrating cells.   Conclusions : Our findings suggest differential expression patterns of MMP-9 and AQP4 in different grades of gliomas. Nuclear translocation of MMP-9 and AQP4 may exert more functions in glioblastoma transition or deterioration. ",
author="Zhao, Wei-Jiang
and Zhang, Wei
and Li, Gui-Lin
and Cui, Yun
and Shi, Zhong-Fang
and Yuan, Fang",
pages="176--186",
url="https://www.termedia.pl/Original-article-Differential-expression-of-MMP-9-and-AQP4-in-human-r-nglioma-samples,20,18867,1,1.html"
}