@Article{Raciborska2012,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="11",
number="3",
year="2012",
title="Comparison of interleukins IL-1β and IL-6 levels, bone mineral density (BMD) and bone metabolism (IBM) in menopausal women",
abstract=" Introduction : Bone metabolism in women is affected among others by estrogens and interleukins.  In the menopausal period, the protective effect of estrogens is lowered and production of interleukins IL-1β and IL-6 is significantly increased.   Aim : To assess the relation between levels of interleukins IL-1β and IL-6, estradiol and bone mineral density (BMD) and bone metabolism (IBM) in menopausal women.   Material and methods : 48 menopausal women, aged 49-61, non-menstruating, without any previous endocrine treatment. Group I comprised 19 women with normal BMD, while group II – 29 women with osteoporosis.   Bone densitometry (BMD and bone density T-score). Radioisotope dynamic and static bone scintigraphy and assessment of bone metabolism index (IBM). Serum: interleukins IL-1β and IL-6, Ca+, ALP, P, E2 and TSH.   Results :  Group I – normal IBM values: 86.2 < IBM < 98.9.  Group II – in 40% of subjects, IBM values below normal: 75.1 < IBM < 90.3.  Group I – strong positive correlation between BMD and IBM.  Group II – moderate positive correlation between BMD and IBM.  Group I – normal values of biochemical and hormonal measurements.   Group II – insubstantial increase of phosphatase and phosphates concentrations.  Interleukin IL-1β and IL-6 levels in group II were significantly higher than in group I (p < 0.0001).  Group I – no relation between BMD and interleukin concentrations .  Group II – relation between BMD and interleukin concentrations was inversely proportional.    Conclusions :  In the menopausal period, a reduction of estradiol concentration is accompanied by an increase of bone-resorbing interleukins IL-1β and IL-6, which leads to reduction of body mass and decelerates bone metabolism.",
author="Raciborska, Iwona
and Sobczuk, Anna
and Tryniszewski, Wiesław
and Kozłowska, Magdalena
and Górska-Chrząstek, Magdalena
and Gadzicki, Mariusz
and Maziarz, Zbigniew",
pages="220--227",
url="https://www.termedia.pl/Comparison-of-interleukins-IL-1-and-IL-6-levels-bone-mineral-density-BMD-and-bone-metabolism-IBM-in-menopausal-women,4,18957,1,1.html"
}