@Article{Kowalczuk-Wieteska2012,
journal="Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej",
issn="1734-9338",
volume="8",
number="2",
year="2012",
title="Surgery with and without extracorporeal circulation in patients aged above 65 and kidney injury assessed by NGAL concentration",
abstract=" Background:  Human neutrophil gelatinase-associated lipocalin (NGAL) is one of the most sensitive predictive indices of acute kidney injury (AKI).    Aim : The aim of the work was to determine whether NGAL is a sensitive predictive index of AKI in elderly patients (> 65 years old) undergoing cardiac surgery, with and without extracorporeal circulation.   Material and methods:  The study group encompassed 30 patients aged > 65 years, treated surgically, 18 with extracorporeal circulation (group I) and 12 without (group II). The serum concentrations of NGAL, cystatin C and the serum glomerular filtration rate (GFR) were assessed 24 h before surgery, and then 2 h and 24 h after surgery. The tests were carried out using immunochemical, nephelometric and standard clinical biochemical methods.    Results : In both groups, pre-operative cardiac, pulmonary and renal functions were normal. Hypertension was successfully treated in 16 patients, diabetes type 2 with normal baseline NGAL and no signs of nephropathy in 4 patients. In group I, the pre-operative levels of NGAL, cystatin C and GFR were normal. Two hours after surgery, there was a statistically significant increase in the level of NGAL, whilst GFR and cystatin C remained unchanged. Twenty-four hours after surgery, NGAL decreased slightly but was still statistically significantly higher than the baseline value. In group II, by contrast, there were no significant differences between pre- and post-operative levels of NGAL, cystatin C and GFR.   Conclusions:  Neutrophil gelatinase-associated lipocalin is the most sensitive biomarker of transient renal ischemia related to the use of extracorporeal circulation in elderly patients with normal pre- and post-operative renal function. In elderly patients with normal renal function before and after cardiac surgery without extracorporeal circulation, NGAL levels are normal.",
author="Kowalczuk-Wieteska, Anetta
and Szewczyk, Marta
and Lindon, Sandra
and Zembala, Marian",
pages="79--84",
doi="10.5114/pwki.2012.29647",
url="http://dx.doi.org/10.5114/pwki.2012.29647"
}