@Article{Słotwiński2012,
journal="Gastroenterology Review/Przegląd Gastroenterologiczny",
issn="1895-5770",
volume="7",
number="3",
year="2012",
title="Alterations in innate antibacterial response after immunomodulatory nutrition",
abstract="Septic infections in malnourished surgical patients show the highest morbidity and mortality rate. The attempt to correct postoperative immune and nutritional disorders by introducing immune-enhancing nutrition (immunonutrition) is a promising way of improving outcome, but as yet little is known about the mechanisms of correcting an extensive postoperative inflammatory response (systemic inflammatory response syndrome [SIRS]) to a massive infection using this type of nutrition. A significant role in the innate antibacterial and inflammatory response is played by Toll-like receptors (TLRs) that recognize pathogen-associated molecular patterns (PAMPs). The regulatory impact of immunonutrition on TLR expression in surgical septic patients seems to be a new research direction. In this paper special emphasis was put on clinical trials and the research results for the TLR-dependent immune response and anti-bacterial/anti-inflammatory response applying immunomodulatory nutrition with increased concentrations of glutamine and unsaturated fatty acids.",
author="Słotwiński, Robert
and Słotwińska, Sylwia
and Kędziora, Sylwia
and Dąbrowska, Aleksandra",
pages="115--124",
doi="10.5114/pg.2012.29876",
url="http://dx.doi.org/10.5114/pg.2012.29876"
}