@Article{Olejek2012,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="11",
number="4",
year="2012",
title="Evaluation of concentration of thyroid antibodies, antinuclear antibody titers and presence of Borrelia burgdorferi antibodies in patients with vulvar lichen sclerosus treated with photodynamic therapy",
abstract=" Aim of study : Lichen sclerosus (LS) is a chronic inflammatory disease of skin and mucous membranes. Autoimmune background has been suggested as a potential pathomechanism of LS development. The aim of our study was to evaluate concentration of thyroid antibodies (anti-TSHR, anti-TG and anti-TPO), antinuclear antibody titers and presence of  Borrelia burgdorferi  antibodies in patients with vulvar lichen sclerosus treated with photodynamic therapy.    Materials and methods:  Serum samples of 64 patients with diagnosed vulvar LS were taken in order to evaluate presence of  Borrelia burgdorferi  antibodies, antinuclear antibody titers and concentration of anti-  TSHR, anti-TG and anti-TPO antibodies before and after PDT therapy (10 courses). As a topical photosensitizer 5% 5-ALA was applied. For ANA evaluation we used an indirect immunofluorescence test (Euroimmun Mosaic HEp2/monkey liver). In 25 cases we performed the ANA Profile 3 Euroline test to identify particular kinds of ANA.   Results:  In the case of anti-TSHR, anti-TPO and anti-TG antibodies, results of quantity values were not statistically significant. We noted a statistically significant decrease of ANA titers after PDT therapy. No differences were shown in the identified fluorescent patterns of ANA before and after PDT therapy. IgG and IgM Anti-Borrelia antibodies were found only in 1 and in no subjects, respectively.    Conclusions:  PDT therapy influences ANA but not anti-TSHR, anti-TPO, anti-TG concentration among patients with diagnosed vulvar LS. In our opinion, Borrelia burgdorferi does not seem to play a significant role in vulvar LS pathogenesis.",
author="Olejek, Anita
and Kozak-Darmas, Iwona
and Olszak-Wąsik, Katarzyna",
pages="275--280",
doi="10.5114/pm.2012.30229",
url="http://dx.doi.org/10.5114/pm.2012.30229"
}