@Article{Goździk2012,
journal="Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery",
issn="1731-5530",
volume="9",
number="3",
year="2012",
title="ANESTEZJOLOGIA I INTENSYWNA TERAPIAInhaled nitric oxide effects outside the lungs – proven and possible mechanisms",
abstract="Inhaled nitric oxide has been shown to reduce pulmonary hypertension in several disease states. The vasodilatory effect of inhaled nitric oxide is limited almost exclusively to the pulmonary circulation, due to its rapid diffusion across the capillary membrane and its immediate deactivation by hemoglobin in the pulmonary vasculature lumen. However, many reports on the use of inhaled nitric oxide have revealed a broad spectrum of changes outside the lung. The remote effects are typically dose dependent and the mechanisms responsible for these effects are incompletely understood. New evidence indicates that nitric oxide inhalation leads to formation of new compounds which may be carried as thiol groups attached to protein in blood or act indirectly through nitrite metabolites. This review presents the mechanisms of inhaled nitric oxide conversion to active compounds/metabolites and discusses their actions beyond pulmonary circulation with special emphasis on the potential for systemic effects.",
author="Goździk, Waldemar
and Goździk, Anna",
pages="352--356",
doi="10.5114/kitp.2012.30848",
url="http://dx.doi.org/10.5114/kitp.2012.30848"
}