@Article{Karbownik2012,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="16",
number="5",
year="2012",
title="The physical and chemical stability of cisplatin (Teva) in concentrate and diluted in sodium chloride 0.9%",
abstract=" Aim of the study : The subject of study was the stability of cisplatin in concentrate in glass vials and diluted in polyethylene (PE) bags stored at 15–25°C for up to 30 days.    Material and methods : Original vials of cisplatin injection (1 mg/ml, Teva) were stored at room temperature and subjected to re-piercing after 1, 2, 3, 7, 14, 21, 28 and 30 days following the initial piercing. Cisplatin infusions at nominal concentrations of 0.1 mg/ml were prepared in 0.9% sodium chloride (1000 ml) in PE bags. Chemical stability was measured by means of a stability-indicating high-performance liquid chromatography (HPLC) assay. Physical stability was assessed by visual inspection in normal light.    Results : The concentration of cisplatin at each sampling time in the analysed solutions remained within 92.0–100.7% of initial concentration, regardless of the container. No changes in colour or turbidity were observed in any of the vials or prepared solutions.    Conclusions : Cisplatin, both undiluted in glass containers and diluted with NaCl 0.9% in PE bags, remains stable (< 10% degradation) for at least 30 days at room temperature when protected from light.",
author="Karbownik, Agnieszka
and Szałek, Edyta
and Urjasz, Hanna
and Głęboka, Aleksandra
and Mierzwa, Emilia
and Grześkowiak, Edmund",
pages="435--439",
doi="10.5114/wo.2012.31775",
url="http://dx.doi.org/10.5114/wo.2012.31775"
}