@Article{Kulig2002,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="1",
number="1",
year="2002",
title="C-erbB2 (Her-2/neu) gene amplification in women with breast cancer \– initial studies",
abstract=" Background.  The c-erbB2 (Her2/neu) oncogene is located on the long arm of chromosome 7, encoding for a 185 kD transmembrane glycoprotein p185 with tyrosine kinase receptor function. Several studies have shown that overexpression of c-erbB2 (Her-2/neu) gene has been associated with breast cancer appearance. The aim of the present study was to investigate the relationship between amplification of c-erbB2 gene and the appearance of breast cancer in menopausal women.   Materials and methods.  Paraffin embedded tumour tissue were obtained from patients with breast cancer (n=20). Blood samples from age matched healthy women (n=20) served as control. The amplification of c-erbB2 gene was determined by PCR reaction using the allele specific primers.   Results.  The amplification of c-erbB2 gene was significantly higher in patients compared as control (p<0.05).  Conclusion.  The results suggest that amplification of c-erbB2 gene may be linked with appearance of breast cancer in menopausal women.",
author="Kulig, Andrzej
and Smolarz, Beata
and Kozłowska, Elżbieta
and Romanowicz-Makowska, Hanna
and Zadrożny, Marek",
pages="11--14",
url="https://www.termedia.pl/C-erbB2-Her-2-neu-gene-amplification-in-women-with-breast-cancer-8211-initial-studies,4,1977,1,1.html"
}