@Article{Siewko2012,
journal="Przegląd Kardiodiabetologiczny/Cardio-Diabetological Review",
issn="1896-9666",
year="2012",
title="Original paperInsulin resistance and fasting plasma glucose in first degree relatives of the patients with type 1 diabetes",
abstract=" Introduction : By the long time of prediabetes period we don’t observe disturbances of carbohydrate metabolism, which lead to the manifestation of the loss of 80-90% of the β cell mass.    Aim : Evaluation of the secretory function of β cells as well as insulin resistance in relation to fasting plasma glucose (FPG).    Material and methods : The study was conducted in 90 I° relatives, which were divided on: “high-normal” FPG group ( 88 mg/dl) and “low-normal” FPG group (< 88/mg/dl). The FPG was determined using enzymatic method. HOMAIR and HOMA%B indices were calculated using computer calculator.   Results:  In 48.9% of patients, a FPG  88 mg/dl was stated. Positive correlations between “high-normal” FPG and body mass index (r = 0.491, p < 0.0001) and between “high-normal” FPG and HOMAIR (r = 0.186, p < 0.002) were observed. A negative correlation between “high-normal” FPG and HOMA%B (r = –0.437, p < 0.0001) were also observed.    Conclusions : The patients with the “high-normal” FPG characterize a higher body mass index, insulin resistance and a higher decrease of β-cell function as compared to a “low-normal” FPG group.",
author="Siewko, Katarzyna
and Popławska-Kita, Anna
and Maciulewski, Rafał
and Zielińska, Anna
and Nikołajuk, Agnieszka
and Górska, Maria
and Szelachowska, Małgorzata",
pages="99--102",
url="https://www.termedia.pl/Original-paper-Insulin-resistance-and-fasting-plasma-glucose-in-first-degree-relatives-of-the-patients-with-type-1-diabetes,47,19869,1,1.html"
}