@Article{Rachoń2002,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="1",
number="2",
year="2002",
title="Effects of transdermal oestrogen replacement therapy on interleukin-6 production in postmenopausal women",
abstract=" Objective:  To investigate the influence of transdermal oestrogen replacement therapy on interleukin-6 (IL-6) production in postmenopausal women.   Design:  Prospective study.   Materials and Methods:  Both the serum levels and spontaneous IL-6 production by peripheral blood mononuclear cells (PBMC) in postmenopausal women were measured before and after 6 and 12 months of HRT using the B9 hybrydoma bioassay. The subjects were 50 healthy postmenopausal women who were divided into two groups. The HRT group (n=30) started receiving transdermal oestrogen (17\&#946;-oestradiol 50 \&#956;g/day) with a 10 day progestogen regimen (oral medroxyprogesteron acetate 10 mg/day). The control group consisted of 20 women who did not agree to HRT.   Results:   At baseline, women from both groups had similar mean IL-6 levels in the sera and PBMC cultures. After 12 months, serum IL-6 levels were significantly lower among women from the HRT group compared to the control group (p<0.05). HRT also decreased spontaneous IL-6 production by PBMC after 12 months (p<0.05).   Conclusions:   Our results indicate that transdermal oestrogen replacement therapy decreases IL-6 production among postmenopausal women. This effect may contribute to the antiatherogenic properties of oestrogens.",
author="Rachoń, Dominik
and Myśliwska, Jolanta
and Suchecka-Rachoń, Krystyna
and Hak, Łukasz",
pages="23--27",
url="https://www.termedia.pl/Effects-of-transdermal-oestrogen-replacement-therapy-on-interleukin-6-production-in-postmenopausal-women,4,1989,1,1.html"
}