@Article{Samancilar2012,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="16",
number="6",
year="2012",
title="The effect of TTF-1 expression on ipsilateral mediastinal nodal (N2) metastases in primary adenocarcinoma of the lung",
abstract=" Aim of the study:  To study the effect of thyroid transcription factor-1 (TTF-1) expression on ipsilateral mediastinal nodal (N2) metastases in primary adenocarcinoma of the lung.   Material and methods:  The patients operated on with a diagnosis of primary adenocarcinoma of the lung were retrospectively analyzed and divided into two groups according to their TTF-1  expression. The relationship between TTF-1 expression and N2 metastases was evaluated.     Results:  There were 73 patients (58 male, 15 female) with a mean age of 58.4 ±10.2 in the study group. Sixty-six lobectomies or pneumonectomies and mediastinal lymph node dissection, and seven mediastinoscopies were performed. Positivity of the TTF-1 protein expression detected by the immunohistochemical staining of the specimens was present in 33 patients (45.2%); these patients were classified as group A and the rest of the patients as group B. Eleven patients had N2 disease in group A  versus  five patients in group B and the difference between the two groups was statistically significant.   Conclusions : Patients with primary adenocarcinoma of the lung having TTF-1 expression are more likely to have N2 disease. They might be considered as candidates for adjuvant therapy.",
author="Samancilar, Ozgur
and Kaya, Seyda Ors
and Ceylan, Kenan
and Usluer, Ozan
and Yener, Ali Galip",
pages="516--519",
doi="10.5114/wo.2012.32484",
url="http://dx.doi.org/10.5114/wo.2012.32484"
}