@Article{Adamczyk2012,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="63",
number="4",
year="2012",
title="Expression of ER/PR/HER2, basal markers and adhesion molecules in primary breast cancer and in lymph nodes metastases: a comparative immunohistochemical analysis",
abstract="The immunophenotypic differences between primary and metastatic tumour cells could influence patient’s treatment or/and the results of selected diagnostic procedures.  That prompted us to investigate potential differences between primary tumours and corresponding synchronous lymph node metastases in the T  1/N+/M0 breast cancer patients. The investigated group consisted of 108 patients with invasive ductal breast cancer, who underwent radical surgery. The expression of ER, PR, HER2 as well as CK5/6, P-cadherin, EGFR and Ep-CAM was assessed immunohistochemically.   Our data suggest that ER, PR, HER2, EGFR and CK5/6 are expressed conservatively, with some minor changes between primary tumour and simultaneous lymph node metastases. On the contrary, Ep-CAM and P-cadherin immunoreactivity in primary and metastatic cells varied significantly. This variation might exclude Ep-CAM and P-cadherin as potential diagnostic or therapeutic targets.",
author="Adamczyk, Agnieszka
and Niemiec, Joanna
and Ambicka, Aleksandra
and Małecki, Krzysztof
and Wysocki, Wojciech H.
and Mituś, Jerzy
and Ryś, Janusz",
pages="228--234",
doi="10.5114/pjp.2012.32769",
url="http://dx.doi.org/10.5114/pjp.2012.32769"
}