@Article{Ece2013,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="17",
number="1",
year="2013",
title="Serum 8-OHdG and HIF-1 levels: do they affect the development of malignancy  	in patients with hypoactive thyroid nodules?",
abstract=" Aim of the study:  This study aimed to evaluate 8-OHdG and hypoxia-inducible factor 1α (HIF-1α) levels in patients with hypoactive thyroid nodules (toxic multi-nodular goiter, Graves’ disease, and Hashimoto’s thyroiditis), as these parameters may be related to oxidative stress and the pathogenesis of cancer.   Material and methods : The study included patients diagnosed with Graves’ disease (n = 20), toxic multinodular goiter (n = 20), and Hashimoto thyroiditis (n = 20), and 20 healthy controls. HIF-1αα levels were measured in blood samples and 8-OHdG levels were measured in urine – both via ELISA.    Results : HIF-1α and 8-OHdG levels were significantly higher in the patient groups than in the control group (p < 0.05).   In the Hashimoto’s thyroiditis patients a correlation was observed between 8-OHdG and thyroglobulin antibodies (p = 0.03). A significant relation was found between 8-OHdG and HIF-1α in the patient group (p   0.05). There was no significant difference in 8-OHdG or HIF-1α levels between the patients with biopsy results that were benign, malignant, and non-diagnostic (p > 0.05).   Conclusions : Serum HIF-1α and urine 8-OHdG levels were significantly higher in the patients with thyroid diseases; however, a relationship with cancer was not observed.",
author="Ece, Harman
and Mehmet, Erdogan
and Cigir, Biray Avci
and Yavuz, Dodurga
and Muammer, Karadeniz
and Cumhur, Gunduz
and Mustafa, Harman
and Sevki, Cetinkalp
and Fusun, Saygili
and Gokhan, Ozgen Ahmet",
pages="51--57",
doi="10.5114/wo.2013.33774",
url="http://dx.doi.org/10.5114/wo.2013.33774"
}