@Article{Wojciechowska2013,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="30",
number="2",
year="2013",
title="Original paperSerum concentrations of metalloproteinase 2, metalloproteinase 9 and granzyme B in contact eczema patients",
abstract=" Introduction : Contact eczema is a common skin condition with complex etiology, variable clinical presentation and lengthy therapy duration. The mechanism of contact eczema is complex, since it is affected by multiple inflammatory mediators.    Aim:  To assess concentrations of metalloproteinase 2 (MMP-2), metalloproteinase 9 (MMP-9) and granzyme B (GzmB) in patients with contact eczema.   Material and methods : Seventy patients with contact eczema and 30 healthy persons as controls were included in the study. In all subjects, MMP-2, MMP-9 and GzmB were determined using ELISA immunoassay. In study group patients, concentrations were assayed in periods of disease exacerbation and remission. Obtained results were analyzed statistically.   Results:  Mean MMP-2 and GzmB concentrations were found to be significantly higher in the study group than in the control group. Mean MMP-2, MMP-9 and GzmB levels were also statistically significantly higher during skin lesion relapse compared to contact eczema remission periods.   Conclusions : The presented paper demonstrates that MMP-2, MMP-9 and GzmB are good markers of contact eczema exacerbations.",
author="Wojciechowska, Milena
and Żbikowska-Gotz, Magdalena
and Czajkowski, Rafał
and Bartuzi, Zbigniew",
pages="73--76",
doi="10.5114/pdia.2013.34154",
url="http://dx.doi.org/10.5114/pdia.2013.34154"
}