@Article{Tharavichitkul2013,
journal="Journal of Contemporary Brachytherapy",
issn="1689-832X",
volume="5",
number="1",
year="2013",
title="Original paperImage-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiotherapy (WP-IMRT) for locally advanced cervical cancer: a prospective study from Chiang Mai University Hospital, Thailand",
abstract=" Purposes : A report of preliminary results and toxicity profiles using image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiation therapy (WP-IMRT) for locally advanced cervical cancer.    Material and methods:  Fifteen patients with locally advanced cervical cancer were enrolled into the study. WP-IMRT was used to treat the Clinical Target Volume (CTV) with a dose of 45 Gy in 25 fractions. Concurrent cisplatin (40 mg/m 2 ) was prescribed during radiotherapy (RT) on weekly basis. IGBT using computed tomography was performed at the dose of 7 Gy × 4 fractions to the High-Risk Clinical Target Volume (HR-CTV).    Results:  The mean cumulative doses – in terms of equivalent dose of 2 Gy (EQD2) – of IGBT plus WP-IMRT to   HR-CTV, bladder, rectum, and sigmoid colon were 88.3, 85.0, 68.2 and 73.6 Gy, respectively. In comparison with standard (point A prescription) dose-volume histograms, volume-based image-guided brachytherapy improved the cumulative doses for bladder of 67%, rectum of 47% and sigmoid of 46%. At the median follow-up time of 14 months, the local control, metastasis-free survival and overall survival rates were 93%, 100% and 93%, respectively. No grade 3-4 acute and late toxicities were observed.    Conclusion : The combination of image-guided brachytherapy and intensity-modulated radiotherapy improved the dose distribution to tumor volumes and avoided overdose in OARs which could be converted in excellent local control and toxicity profiles.",
author="Tharavichitkul, Ekkasit
and Wanwilairat, Somsak
and Chakrabandhu, Somvilai
and Klunklin, Pitchayaponne
and Onchan, Wimrak
and Tippanya, Damrongsak
and Nopnop, Wannapa
and Galalae, Razvan
and Chitapanarux, Imjai",
pages="10--16",
doi="10.5114/jcb.2013.34338",
url="http://dx.doi.org/10.5114/jcb.2013.34338"
}