@Article{Wysocki2013,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="17",
number="2",
year="2013",
title="Preoperative radiotherapy does not alter pre- and early postoperative serum CRP and albumin concentrations in colorectal cancer patients",
abstract=" Aim of the study : We aimed to assess the alterations of serum C-reactive protein (CRP) and albumin levels in colorectal cancer patients who underwent preoperative radio(chemo)therapy and those who did not.   Material and methods: The determinations of albumin and CRP were performed before and at 2, 3, 5 and 7 days after surgery in 60 colorectal cancer patients. 25 healthy subjects served as a reference group. For each patient the modified Glasgow Prognostic Score (mGPS) was calculated.    Results:  On the operation day CRP and albumin concentrations were not different in preoperatively treated or radiotherapy naI..ve patients. On postoperative day 2, 3, 5 and 7 no significant differences were observed between the two groups, with the only exception for albumin concentration, which was significantly higher on postoperative days 2 and 7 in the radiation naI..ve group. In all patients perioperative alterations of serum CRP level were significant at all time points (preoperatively vs. day 2, day 2 vs. day 3, day 3 vs. day 5, day 5 vs. day 7). The albumin decrease from the preoperative day to postoperative day 2 was significant, as was its increase from postoperative day 3 to 5.   Conclusions : We have seen no differences in the CRP and albumin concentrations in preoperatively irradiated  versus  non-irradiated colorectal cancer patients on the day of surgery and on postoperative days 2, 3, 5 and 7. There were, however, significant concentration changes in the value of these two serum markers from preoperatively to postoperative day 2 and over the following postoperative week, but presumably related to the surgical trauma, not the neoadjuvant treatment.",
author="Wysocki, Wojciech M.
and Stasik, Zofia
and Darasz, Zbigniew
and Jakubowicz, Jerzy
and Tarapacz, Jadwiga
and Kulpa, Jan Kanty",
pages="161--164",
doi="10.5114/wo.2013.34620",
url="http://dx.doi.org/10.5114/wo.2013.34620"
}