@Article{Wei2013,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="17",
number="3",
year="2013",
title="Expression of β-catenin and AXIN2 in ameloblastomas",
abstract=" Aim of the study:  To investigate the ex­pression status and association of β-ca­tenin and AXIN2 in ameloblastoma.   Material and methods : 30 ameloblastoma specimens and 10 normal oral mucosa tissues were enrolled in the study. The protein and RNA levels of   β-ca­tenin and AXIN2 were detected by immunohistochemistry staining, Western blot, and real-time PCR analysis. The relationship between β-catenin and AXIN2 protein and clinico-pathological parameters and prognosis was subsequently determined.   Results:  The results show that β-catenin mRNA expression was 1.24-fold higher in ameloblastomas than that in normal mucosa tissues, but AXIN2 mRNA expression was 0.47-fold lower in ameloblastomas than that in normal mucosa tissues (p < 0.05). The Western blot results show that β-catenin and AXIN2 protein in ameloblastomas had a significantly higher level than normal mucosa tissues   (p < 0.05). Immunohistochemical staining of β-catenin and AXIN2 protein in ame­loblastoma was expressed at a higher level than normal oral mucosa (p < 0.05).   Conclusions : AXIN2 and β-catenin play an important role in the tumorigenesis and progression of ameloblastoma.",
author="Wei, Zhenhui
and Zhong, Ming
and Guo, Yan
and Wang, Yan
and Ren, Meisi
and Wang, Zhaoyuan",
pages="250--256",
doi="10.5114/wo.2013.35278",
url="http://dx.doi.org/10.5114/wo.2013.35278"
}